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Broad evidence base
Dopaminergic Pathways Levodopa's primary mechanism is straightforwardas the metabolic precursor to dopamine, it crosses the bloodbrain barrier and is converted to dopamine, thereby replenishing the neurotransmitter that is deficient in PD [21]
Suenaert, P
10.1089/ther.2012.0016 182
The importance of moderate hyperhomocysteinemia, and of other conventional risk factors such as age and sex, on the incidence of vascular pathologies are stressed in a recent case-controlled study conducted in nine European centers (Graham et al, 1997)
