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Description
HSCs are relatively more sensitive to oxidative stress, which may be partly because they are usually located in a hypoxic environment in the HSC niche and maintain in a quiescent state

Sikiric et al., 2020a)

As the mitochondrial membrane potential drops, this triggers the opening of the mitochondrial permeability transition pore, resulting in the release of cytochrome C and various other apoptotic factors from the mitochondria into the cytoplasm

IV GSH is successful and expensive
Mild injection-site soreness or temporary B-vitamin flush may occur
