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In preclinical models of PDAC, while ablation of the tumour-restrictive -SMA + CAFs reduced survival, depletion of FAP + CAFs significantly improved survival and enhanced the efficacy of immune checkpoint inhibitors (ICIs) [243]

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By including appropriate controls, such as non-specific beads or unrelated proteins, researchers can distinguish specific interactions from background noise

In Pharmaceutical product development (Chapter 22)

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