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Uncontrolled or prolonged autophagy may lead to excessive degradation of essential cellular structures, thereby accelerating cell death and exacerbating myocardial injury [3, 98, 143]

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Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

On the other hand, glutarate hydroxylase CsiD is subject to weak product inhibition (Knorr et al., Moreover, a weak substrate inhibition on l-2HG production by glutarate could also be identified (Figure 5B)

Comparative mechanistic study of Rpe cell death induced by different oxidative stresses
