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Unfortunately, our study did not investigate the effects commonly thought (for review see, (25)) to cause endothelial damage such as decrease in the relaxing effect of NO/EDRF (28), ADP, thrombin, Ca2+-ionophore A-23187 on endothelium

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Other relevant pharmacokinetic parameters of D-Nle-Tyr-Ile-NH-(CH 2 )s-CONH 2 after a single IV bolus dose are summarized in Table 5