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Ann Clin Transl Neurol 7(11):23322338
"Kaiser Permanente No
2002 Apr
They found that under basal conditions without Mn 2+ supplementation, endogenous labile Mn 2+ is confined to sparse punctate foci, consistent with a compartmentalized intracellular pool
Similarly, the SHP2 inhibitor RMC-4550, as well as the SOS1 inhibitors RMC-0331 and BI-3406, were used to prevent ERK reactivation in BRAFi and MEKi persisters 32
