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Cancer organoids from mice were cultured in tumour organoid medium (CM) composed of Advanced DMEM/F12 (Gibco, 12634) supplemented with 1% penicillinstreptomycin solution, 0.1% BSA, 2 mM l-glutamine, 10 mM Hepes, 50 ng/mL EGF (PeproTech AF-100-15), 100 ng/mL Noggin (PeproTech 250-38), 500 ng/mL Spondin (PeproTech 120-38), 1X N-2 Supplement (ThermoFisher 17502048) and 1X B-27 Supplement (ThermoFisher 17504044)

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TdGSH prevented LOsG-induced functional failure of dedifferentiated -cell via the FoxO1/TXNIP pathway Pancreatic -cell dedifferentiation is one of the mechanisms resulting in diabetic -cell failure