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Under conditions of compromised mitochondrial function, the proton-motive force falls below the threshold required for ATP synthesis and the activity of ATP synthase can actually reverse such that it hydrolyzes ATP to pump protons back into the inner membrane space

Low glutathione is linked to accelerated aging, chronic disease, neurodegenerative conditions, and impaired detoxification

10.1111/j.1471-4159.1989.tb09150.x

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