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Description
The GDH2 complex is not inhibited by GTP which allows astrocyte GDH2 to continue to function under conditions of intense excitatory neurotransmission allowing these cells to handle the increased loads of the neurotransmitter glutamate
Kelly, B
Dickey DT, Wu YJ, Muldoon LL, Neuwelt EA
, Grothaus I
However, how changes in the redox status itself could impact the intracellular Ca 2+ homeostasis in astrocytes is not known, although this could be of great help to understand the neuronal damage caused by oxidative stress
