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Human skin models, including reconstructed epidermis and diseased or barrier-compromised tissue, therefore provide more clinically relevant information for evaluating permeability and optimizing topical formulations

10.1016/j.indcrop.2014.10.026 24 Demir.nbolM.AypakS

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In addition, induction of apoptosis mediated by a dysregulated immune system and upstream regulation of inflammatory mediators has been observed by research studies

Although innovations such as vascularization, genome editing, omics-techniques, high-content imaging (HCI), machine-learning-based and automated systems are already a reality in organoids, protocols need to continue evolving to improve tissue communication, cell patterning signals, body axis simulation and spatial-temporal control of differentiation (Lokai et al., 2023)