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In all of the proposed methods the whole blood sample will be added to the device, followed by an integrated whole blood processing step to yield a plasma sample
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Moreover, the risk of vitamin B12 deficiency also increases with increased metformin dose and duration of its use
The universally accepted standard, supported by USP (United States Pharmacopeia) guidelines and manufacturers, is 28 days
Additionally, some evidence suggests that B12 deficiency can increase the risk of developing diabetes
