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Some people notice the energy boost from B12 injections within a few hours
Alpha-lipoic acid may potentiate the blood-glucose-lowering effects of insulin or sulfonylureas, increasing hypoglycaemia risk
People with severe malabsorption, pernicious anemia, or advanced deficiency may not respond adequately to oral supplements alone
A clarifying question would be if brain metabolites, as measured by MRS, were also altered by exogenous proinflammatory cytokine injection or peripheral immune challenge
