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Since one of the primary functions of glutathione is to neutralize free radicals and combat oxidative stress, excessive alcohol consumption, and smoking may counteract the benefits of glutathione

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doi: 10.1016/j.freeradbiomed.2010.04.004

Thus, cytoprotective systems, such as the heat shock response, and the body antioxidant system appear to be preserved and effectively activated in response to muscle injury and inflammation induced by intense resistance training
PMID: 23294312
