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"Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas." Experimental Gerontology

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This results in downstream signaling responses such as intracellular second messenger activation or ion channel opening

We have included substrate activation (the Hill term on the right) and found that if we omitted this substrate activation then the cytochrome oxidase reactions did not produce enough NAPQI at high overdoses