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doi: 10.1016/j.peptides.2022.170864 126 DevinJLHillMMMourtzakisMQuadrilateroJJenkinsDGSkinnerTL

She presented with severe hypermanganesemia, hepatic Mn accumulation, Mn deposition in the basal ganglia, and clinical manifestations that included an altered gait, mild hepatic cirrhosis, and polycythemia

Recently, it was suggested that autophagy, nutrition-induced, exerts a high potential in the prevention and therapies of chronic diseases ( BECN1, MTOR , ULK2 (Unc-51Like Autophagy activating Kinase 2), BCL2.2 (B-cell lymphoma)

However, crystallization of such mutants is also required for a better understanding of structure and function

Indeed, the active form of vitamin D is generated not only in renal tubular cells but also in extrarenal target tissue cells, and its functions are autocrine, paracrine, and endocrine