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The first tumor metabolic adaptation was identified by Otto Warburg in the 1920s, who described that cancer cells have an exacerbated glucose uptake and glycolysis accompanied by increased lactate production even under aerobic conditions ( Uncontrolled cell division exhibited by cancer cells introduces a cellular metabolic challenge, since it is necessary to double the total biomass (nucleic acid, proteins, and lipids) to support the mitotic cell division of a single cell into two equal-sized daughter cells

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[DOI] [PubMed] [Google Scholar] 22.Hauet T., Baumert H., Gibelin H., Godart C., Carretier M., Eugene M

Lancet (London) 360:219223 Burlina AP, Sershen H, Debler EA, Lajtha A (1989) Uptake of acetyl-l-carnitine in the brain