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A recent study analyzed the circulating microbiome of patients with alcoholic hepatitis, and found a decrease in Bacteroidetes and an enrichment of Fusobacteria

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Notably, these macrocyclic peptides exhibit noncompetitive behavior with either SAM or NAM, suggesting that they may function as allosteric inhibitors targeting NNMT (Van Haren et al., 2021)

2008;59:S84-87