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Abstract GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60

Comparative effectiveness research with established therapies would help determine the relative benefits and risks of these peptides compared to current standard treatments and would inform evidence-based treatment decisions

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Thus, short-term activation of GH-RH receptors by GH-RH agonists in vitro leads to stimulatory effects, but chronic, long-term, persistent exposure to these ligands produces a downregulation of receptors and inhibitory effects 58,67