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They found that NNMT knockdown reduced the insulin level and improved glucose tolerance in female mice fed with a Western diet and that NNMT knockout strongly improved insulin sensitivity in male mice fed with a high-fat diet [28]

A corresponding moderate increase in the functional metabolic biomarkers plasma methymalonic acid and homocysteine suggests that some depletion of maternal intracellular vitamin B12 has occurred even though serum B12 concentrations are high (Varsi et al., 2018)

Even changing the oral supplement to a sublingual tablet or lozenge has not been found to drastically change absorption rates (20, 21)

Making the Decision: Is a Vitamin B12 Shot Right for You

Kaplan, B., & Smith, A