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Shen YX, Zhang N, Tian JL, Xin G, Liu L, Sun XY, et al

doi: 10.3389/fphar.2025.1599816 Received 25 March 2025 Accepted 16 June 2025 Published 22 July 2025 Volume 16 - 2025 Edited by Andrs Trostchansky, Universidad de la Repblica, Uruguay Reviewed by Satish Balasaheb Nimse, Hallym University, Republic of Korea Hctor Leonardo Montecino-Garrido, Center for Processed Food Studies, Chile Updates Copyright 2025 Tauchen, Huml, Jurek, Regenstein and Ozogul

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DO NOT USE if particulate matter or discoloration is observed

Moreover, since eukaryotes segregate the TCA cycle within the mitochondria while RNR is exclusively cytosolic [86], it is unlikely that the eukaryotic TCA cycle could be similarly modified to directly support DNA precursor production