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These include the rule of exponents method, which uses maximum lifespan potential and brain weight to correct the exponent,15 liver blood flow,20 and correction for in vitro metabolic clearance.21 The method of choice will depend on the PK characteristics of the drug candidate and the data available for scaling
Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily
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A study on lncRNA PVT1 mechanism revealed that lncRNA PVT1 targeted miR-152, which promoted chemoresistance of OS by activating c-MET/PI3K/AKT pathway (Sun Z
2023;83:4239e42544210
