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Lastly, we provide a unique set of data comparing the molecular alterations found in human ALS patients skin fibroblasts and SODG93A mouse motor neurons, revealing conserved changes in protein translation, folding and assembly, tRNA aminoacylation and cell adhesion processes.

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This in silico framework provides a platform from which GSH depletion can be explored as a function of a compounds physicochemical properties.

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Specifically, the administration of FOS and GOS decreases the expression of TLR4, TNF-, IL-1, and MMP9 and increases the expression of occludin and IL-10