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Tumor microenvironment mediated spermidine-metal-immunopeptide nanocomplex for boosting ferroptotic immunotherapy of lymphoma

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Kinetic analysis of Arabidopsis GCL showed that the enzyme was inactivated by buthionine sulfoximine, a potent inhibitor of mammalian GCL, and used a random ter-reactant kinetic mechanism with a preferred order of binding for catalysis (Jez et al., 2004)