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4.1 ACLY and cancer The synthesis of lipids is a crucial process in lipid metabolism, providing energy substrates for the malignant proliferation of tumor cells
The resultant glycerol-3-phosphate is then converted to the glycolytic intermediate, dihydroxyacetone phosphate (DHAP), via the action of cytosolic glycerol-3-phosphate dehydrogenase (GPD1), and is utilized for glucose synthesis via the gluconeogenesis pathway
Mol Cell Biol 22:59755988
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