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Description
Shah JJ, Weber DM, Thomas SK, Alexanian R, Wang M, Qazilbash MH, Parmar S, Shah N, Bashir Q, Popat UR, Hilder B, and Orlowski RZ

During the HSR, the guardian of cytoplasmic proteostasis, genes encoding heat shock proteins (HSPs) are upregulated by the heat shock transcription factor HSF1 2,3,4
PMID 4713201

Two days after induction, cells were switched to a maintenance medium containing 10%FBS, P/S, insulin, T3 and rosiglitazone

The body can make it, but demand may rise during illness, injury, intense training or other metabolic stress
