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Description
Gastrointestinal adverse reactions were reported by 31 (72%) of the 43 patients in the pediatric clinical trial

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And this becomes especially true when you take into account the fact that Life Extension tends to use trademarked names for its supplements seeing Pycnogenol on the A to Z list with no other information will likely leave people wondering exactly what that is

Long-term use considerations Limited long-term human data means extended use involves some uncertainty

Compared to control rats, those treated with FAEs showed lower levels of C-reactive protein, IL-6, and TNF-
