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Wibel R., Knoll P., LeVinh B., Kali G., BernkopSchnrch A., Acta Biomater

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[3] Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH

B: However, in the endothelial cells with high level of phosphor AKT, following the block of VEGF stimulation, the AKT pathway remains active inducing transcription of FGF, an angiogenic factor, which on one side promotes endothelium proliferation and on the other further phosphorylates AKT producing a positive loop

And we learned that from patients with traumatic brain injury that when you get a traumatic brain injury within 30 to 60 minutes of the brain injury, you actually get an increase in gut permeability and then you get a lot of inflammation coming into the body that then affects the brain