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Mechanistically, hyperoside inhibits cyclin-dependent kinase 6, thereby promoting dephosphorylation and nuclear translocation of transcription factor EB, which in turn upregulates PGC-1 and uncoupling protein 1 to activate thermogenic programs in adipose tissue

Table 1 Demographics for patients at baseline

10.1016/j.ymgme.2017.07.011 41 ter VeldF.PrimassinS.HoffmannL.MayatepekE.SpiekerkoetterU

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