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Oct 2020;111:154336

Direct provision of TMAO into diet has been shown to increase the development of atherosclerosis in animal models, confirming its pro-atherogenic properties 47 , and multiple clinical studies have confirmed that an elevated TMAO level is associated with increased risks for incident major adverse CV events 48

This could be in the form of trabeculae from atrial appendages of cardiac surgery patients or myocardial preparations isolated from transplanted human hearts

Adverse Reactions/Side Effects Clinical Trials Experience Transient nausea and vomiting have been observed

[DOI] [PMC free article] [PubMed] [Google Scholar] 44