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Upon exposure of HCC cells to specific ferroptosis inducers (e.g., Sorafenib, erastin, etc.), the expression of P62 increases and prevents the degradation of Nrf2 protein by competitively binding to Keap1 protein, and promotes the entry of Nrf2 into the nucleus [134], where nuclear Nrf2 can bind to transcriptional co-activators such as Maf protein and activate a series of downstream ferroptosis-related proteins, especially antioxidant proteins transcription, including NADH Dehydrogenase, Quinone 1 (NQO1), heme oxygenase-1 (HO-1), and FTH1 [135,136,137,138]

It turned out that glutamine deprivation suppressed cell proliferation and induced apoptosis in all cell lines tested [18]

The authors concluded that WISP1 causes liver I/R damage in mice through TLR4/TRIF signaling, and both factors play a synergistic role in hepatic IRI 414 (Fig