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Preclinical studies and clinical trials evaluating CD38 inhibition are ongoing in patients with either solid tumors or hematological malignancies, including MM ( 2.4 CD38 enzyme activity and therapeutic antibodies: potential influence on refractoriness A crucial question is whether the binding of therapeutic CD38 antibodies interferes with the enzymes functional activity

Targeting NAD(+)/PARP DNA repair pathway as a novel therapeutic approach to SDHB-mutated cluster I pheochromocytoma and paraganglioma