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10.1016/j.phymed.2018.11.020 Summary Keywords acetaminophen, liver injury, natural products, oxidative stress, Nrf2 Citation Liao J, Lu Q, Li Z, Li J, Zhao Q and Li J (2023) Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products

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Phase I enzymes mediate oxidation, reduction, and hydrolytic reactions of xenobiotics, including NQO1, carbonyl reductases (CBRs), aldo-keto reductases (AKRs), and aldehyde dehydrogenase 1 (ALDH1), and certain cytochrome P450 oxidoreductases cytochrome P450s (CYPs) [71]

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