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Vitro 62 , 104700 (2020)

Magnetic Resonance in Medicine, 82(2), 527550

These are mediated by 11-hydroxylase (P450c11 or CYP11B1), which generates cortisol (followed by activities of the ER enzymes P450c21 and P450c17), and aldosterone synthase (P450c11AS or CYP11B2) which produces aldosterone 91,92,93,94

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Meanwhile, the GH-IGF1 signaling involved in DNA damage response (DDR) and DNA damage repair determines the radio-resistance of cancer cells subjected to radiotherapy and repair of adjacent tissues damaged by radiotherapy