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The Journal of Pharmacology and Experimental Therapeutics has retracted this article. In September 2024, Athira Pharmas LIFT-AD trial of fosgonimetona clinical derivative of Dihexafailed to meet primary and secondary endpoints in 312 mild-to-moderate Alzheimers patients

Lancet (2017) 389(10070):72734

The pharmacokinetics matter for any compound, and theyre not characterized for Dihexa in published human work

This includes people with: Pernicious anaemia (autoimmune destruction of intrinsic factor-producing cells), typically requiring lifelong IM injections Crohn's disease or surgical resection affecting the terminal ileum Coeliac disease causing malabsorption (may improve with gluten-free diet) Chronic pancreatitis reducing enzyme availability needed for B12 release Vegans and strict vegetarians need reliable B12 sources through fortified foods or supplements, as plant-based diets contain negligible amounts of active B12