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I am in a way lucky as the best I could hope for in the USA was loading once a month and oral B12 and folic acid

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In conclusion, the present study demonstrates that the diurnal rhythm of GC signaling is involved in the control of the bladder peripheral clock and a mismatch between the central and peripheral bladder clocks decrease the diurnal rhythm of volume voided per micturition

Any underlying medical issues would need to be treated