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doi: 10.1038/nature05414

In the event DSIP does ultimately undergo clinical development, intranasal administration can ensure a higher degree of patient compliance by eliminating side effects and discomfort commonly associated with peptide injections

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This upregulation of CYP2E1 explains, in part, the metabolic tolerance to alcohol and the cross-tolerance to other drugs that are also substrates of CYP2E1, such as pentobarbital and diazepam, in people with AUD (90)

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