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Acetyl-Carnitin-Ester: Diese Verbindungen sind auch Teil der krpereigenen -Oxidation, sind allerdings in knstlicher Variante in der EU nicht zugelassen

Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA

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Acquired carnitine deficiency Hemodialysis and kidney disorders In the kidney, osmolytes including carnitine are crucial since hypertonicity is usual and the kidney must cope with fluctuations of diuresis (increased production of urine) and antidiruesis