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R-alpha-lipoic acid, the naturally occurring form, may offer advantages over synthetic alpha-lipoic acid, which contains both R and S enantiomers
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Furthermore, genetic evidence for the contribution of ferroptosis to kidney damage upon I/R has been provided using mice with a targeted active site selenocysteine to cysteine mutation within the key ferroptosis regulator GPX4 U46C
Thus, cancer treatment strategies have focused on pharmacological inhibition of these transporters
