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However, the age-induced increase in ROS finally compromises the Zn-binding capacity of MTs (128)
282 Mechanistically, this might occur via the downregulation of TJ-related mRNA expression (e.g., occludin, CLDN1/3/4, and ZO-1)
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So even within KLOW, the evidence is uneven: strongest for the anchor, progressively more speculative for the supporting peptides
However, importantly, the absolute number of TAMs per tumor weight did not change (Figure 2D)
