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Side-effects such as acne, depression, bloating, irregular, prolonged and breakthrough bleeding, headaches, nausea and weight gain, and an increased risk of venous thrombosis for combined contraceptives can occur

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6 Novel therapeutic avenues and future directions 6.1 Immunotherapy and targeted molecular treatments Recent studies have identified the calcitonin gene-related peptide (CGRP)/receptor activity modifying protein 1 (RAMP1) signaling axis as a critical player in endometriosis pathophysiology, with implications for both lesion development and pain generation ( 6.2 Ferroptosis modulation and oxidative stress control Iron overload resulting from periodic bleeding is a characteristic feature of endometriosis, which contributes to oxidative stress and plays a crucial role in the pathogenesis of endometriosis and its associated infertility
[18] Tinospora cordifolia (Guduchi) immunomodulatory study
