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Specifically, CBD significantly reduces cell viability, likely through antagonizing the transient receptor potential melastatin type-8 (TRPM8)

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268 Inflammatory cytokines (e.g., IL-6 and TNF-) upregulate the expression of CYP24A1 in colon cancer cells by activating the NF-B pathway, which in turn leads to abnormal activation of the Wnt/-catenin pathway and promotes disease progression
