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2-Oxoglutarate as Signaling Molecule 2-Oxoglutarate (-ketoglutarate) is the ligand that activates the GPCR that was originally identified as GPR99/GPR80 but is now identified as the 2-oxoglutarate receptor 1 and is encoded by the OXGR1 gene

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Oxidative stress and the pathogenesis of cholestasis

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This makes the arginate version significantly more stable in liquid and across various pH levels, especially in the acidic environment of the stomach

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