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The presence of signs of denervation in distal muscles at lower limbs is expected on EMG as well as atrophy of muscles together with weakness and instability to walk due to sensory deficits at feet

This microbial imbalance suppresses the production of protective metabolites (e.g., -linolenic acid and oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine) while promoting the accumulation of pathogenic metabolites like arginine, ultimately compromising metabolic homeostasis and aggravating lupus symptoms [55]

DDD mitigates AS by preventing vascular fibrosis, preserving endothelial function, and reducing plaque rupture (Ren et al., 2017

(2006) Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model