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Emerging research directions include investigation of senescence heterogeneity and tissue-specific senescent cell populations, with FOXO4-DRI serving as a tool for studying how different senescent cell types contribute to various pathological processes

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According to our experimental approach, (i) CoQ10 appeared to be the most effective antioxidant inducing a high increase in ATP/ADP, ATP/AMP, GSH/GSSG ratio and ORAC value and, in turn, a reduction of NAD concentration, (ii) EGCG modestly modulated the intracellular energy charge potential, while (iii) Vitamin E, vitamin C, and resveratrol exhibited very weak effects