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Description
Xanthine dehydrogenase (XDH) requires Moco, FAD, and two iron-sulfur clusters (Hille et al., 2011), and its main function is associated to purine degradation by oxidizing hypoxanthine to xanthine and xanthine to uric acid in the cytosol
Levengood, M
Further evidence that Treg cells require ETC function comes from the observation that Treg cellspecific genetic loss of mitochondrial complex III function incurs fatal autoimmunity and increases antitumor immunity
Uric acid is reduced in the substantia nigra in Parkinsons disease: effect on dopamine oxidation
M.BelmonteF.BelsitoD.BisertaS.BotelhoD.BruzeM.et al (2019)
