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Silencing of lipocalin2 improves cardiomyocyte viability under iron overload conditions via decreasing mitochondrial dysfunction and apoptosis [J]

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29 This category of antioxidants is also referred to as the second line of defense

designed a US-triggered MnWO X nanosystem modified with PEG (termed MnWO X -PEG) to endow the capability of GSH-enhanced ROS ( 1 O 2 and OH) production for killing malignant tumors (Figure 6D) ( X -PEG exhibited significantly time-dependent GSH consumption capacity through reducing W 6+ to W 5+ (Figure 6E), cooperating with increased ROS to achieve a powerful inhibition effect on tumors (Figure 6F)

The first step of LOXs catalysis is to abstract an unstable hydrogen from the bis -allyl position at a PUFA to form a pentadienyl radical (L) (Kuhn et al., 2015)
