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Myeloid differentiation protein2 has been identified to activate TLRs, and participation in TLR4-NOX4 complex formation may contribute to oxidative and inflammatory damage [316]

Notably, in recipients of ECD organs included in the Scientific Registry of Transplant Recipients, overall graft loss was not significantly different between recipients with higher CIT and paired donor recipients with lower CIT (28)

G6PD is the first rate-limiting enzyme of the PPP oxidative branch, and its enzymatic activity is intimately involved in regulating the PPP pathway that impacts cell proliferation [39, 40]

Figure 2 illustrates the molecular pathways involved in IC
