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In a folic acid-induced animal model of AKI, ferroptosis has been implicated in the development of renal fibrosis [100, 101]
Notably, purified PLA 2 lacks hydrolytic activity against erythrocyte membrane phospholipids, but its combination with melittin synergistically enhances hemolysis beyond that achievable by either component alone ( Skeletal and cardiac muscle cell membranes exhibit greater resistance to PLA 2 , although both crude venom and melittin exert toxic effects on the cardiovascular system
(2016), Indian Dermatology Online Journal , reviewed glutathione's proposed mechanisms and use in skin lightening, noting that while plausible biologically, larger and longer-term trials are still needed
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