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doi: 10.3390/cells9071687

The simulation results from the integration of oxidative stress with the complete C1 metabolism system reveal increases in formaldehyde accumulation and concomitant glutathione depletion, as shown in Figure 9(a) and Figure 9(b), respectively

For example, the negative charge of DNA molecules, which leads to electrostatic repulsion and impairs the passive transport of nanoparticles in tissues

These challenges underscore the urgent need for innovative drug development to establish safer, more effective precision treatment paradigms for this recalcitrant malignancy [16,17,18,19]