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Description
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Without some UV exposure, the melanocytes won't receive the final signal to produce and distribute the melanin
The active form of MAPKKK phosphorylates MEK1/2 (MAPKK), which in turn phosphorylates ERK1/2 (MAPK), favoring its nuclear translocation and activation of target transcription factors (90)
The injection form bypasses intestinal absorption limitations (intrinsic factor dependence), so patients with malabsorption issues may benefit more from injectable B12 than oral supplementation
Epidemiological and modeling insights
